2015 Grant Recipient – Candice Myers

Identifying Genetic Causes of LGS Dr. Candice Myers, PhD University of Washington   Results: Pending   Lay Abstract: Developmental and epileptic encephalopathy (DEE) is a group of conditions characterized by the co-occurrence of epilepsy and intellectual disability (ID), typically with…

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2015 Grant Recipient – Robert Hunt

CHD2 model for LGS Dr. Robert Hunt, PhD University of California Irvine   Results: Pending   Lay Abstract: I have been an active member of the Department of Anatomy & Neurobiology at UC Irvine since joining the faculty in 2015….

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2016 Grant Recipient – Nicholas Poolos

Large scale analysis of antiepileptic drug efficacy in Lennox-Gastaut Syndrome Dr. Nicholas Poolos, MD, PhD University of Washington   Results: Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy Lay Abstract: Refractory epilepsy is defined as…

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2017 Grant Recipient – Aaron Warren

Identifying neuroimaging predictors of treatment outcomes following deep brain stimulation in patients with Lennox-Gastaut Syndrome Dr. Aaron Warren, PhD University of Melbourne, Australia   Results: Coming soon Cortex leads the thalamic centromedian nucleus in generalized epileptic discharges in Lennox-Gastaut syndrome…

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2017 Grant Recipient – Vanesa Nieto-Estevez

Modeling Lennox-Gastaut Syndrome in Human Cerebral Organoids Dr. Vanesa Nieto-Estevez, PhD UT Southwestern Medical Center   Results: Pending CHD2: One Gene, Many Roles Lay Abstract: Lennox–Gastaut syndrome (LGS) is a devastating epileptic encephalopathy in children characterized by multiple seizure types…

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2018 Grant Recipient – Kay-Marie Lamar

Defining the Molecular Mechanisms of CHD2 in LGS Dr. Kay-Marie Lamar, PhD Northwestern University   Highlights: Dr. Lamar’s work showed that CHD2 has a unique role in human brain development and function. Mutations in this gene can lead to DNA…

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2019 Grant Recipient – Zin-Juan Klaft

GluN2D – dependent maturation of cortical interneurons and epilepsy – co-funded with the American Epilepsy Society Dr. Zin-Juan Klaft, PhD Tufts University   Results: Coming soon Tonic Activation of GluN2C/GluN2D-Containing NMDA Receptors by Ambient Glutamate Facilitates Cortical Interneuron Maturation Lay…

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2019 Grant Recipients – Daniel Shrey, Beth Lopour, & Mary Zupanc

The Effects of Felbamate on the Evolution of LGS Children’s Hospital of Orange County Results: Several small case series provide conflicting impressions of the efficacy of felbamate for treatment of epileptic spasms. Using a large single-center cohort of children with…

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2019 Grant Recipient – Colleen Carpenter

Dissecting the Interplay Between Genetic and Metabolic Deficits in LGS using Zebrafish Dr. Colleen Carpenter, PhD University of California, San Francisco   Results: Genetic engineering techniques have contributed to the now widespread use of zebrafish to investigate gene function, but…

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2020 Grant Recipient – Jennifer Kearney

RNA Modulation in KCNB1 Model of LGS Dr. Jennifer Kearney, PhD Northwestern University Feinberg School of Medicine   Highlights: Evaluated mouse model with a Kcnb1-associated LGS mutation. Applied antisense oligo to knockout mutant Kcnb1. Assessed neurological and behavioral symptoms in…

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