Improving the management of seizures in children with Lennox-Gastaut Syndrome Babitha Haridas, MBBS Johns Hopkins Medicine Highlights: Establishing a tailored approach to treating LGS children with prolonged seizures or status epilepticus. Identify factors triggering status epilepticus and refractory status…
Low Glycemic Index Treatment in Patients with LGS Elizabeth Thiele, MD, Ph.D. Massachusetts General Hospital Lay Abstract: Lennox-Gastaut Syndrome (LGS) is a highly refractory seizure disorder characterized by multiple seizure types, a slow spike-and-wave EEG pattern, and cognitive…
Preclinical therapeutic development using an ARHGEF9 mouse model of LGS Christopher Makinson, PhD Columbia University Highlights: Mutations in ARHGEF9 is causal for developmental and epileptic encephalopathy (DEE). Mouse model of ARHGEF9-DEE exhibit several types of spontaneous seizures including generalized…
A Zebrafish Model for LGS Dr. Brian Grone, PhD University of California, San Diego Highlights: Mutations in the synaptic gene STXBP1 are linked to childhood epilepsies and neurodevelopmental disorders, including LGS Zebrafish STXBP1 homologs (stxbp1a and stxbp1b)…
North American Consensus for the Diagnosis and Management of Lennox-Gastaut Syndrome Highlights: To date, expert consensus recommendations for the care and treatment for LGS patients significantly vary from one another. A broad, systematic and comprehensive study to establish consensus recommendation…
Identifying Genetic Causes of LGS Candice Myers, PhD University of Washington Highlights: Performed whole-genome sequencing and targeted next-generation sequencing on DNA from patients with developmental and epileptic encephalopathy (DEE) and Infantile Spasms (IS) to identify underlying genetic causes of…
CHD2 model for LGS Robert Hunt, PhD University of California Irvine Results: Pending Lay Abstract: I have been an active member of the Department of Anatomy & Neurobiology at UC Irvine since joining the faculty in 2015. My…
Large scale analysis of antiepileptic drug efficacy in Lennox-Gastaut Syndrome Nicholas Poolos, MD, PhD University of Washington Highlights: Analyze a large cohort of antiepileptic drugs to better serve LGS patients Utilizing the SeizureTracker dataset, a self-reported, online dataset collected…
Identifying neuroimaging predictors of treatment outcomes following deep brain stimulation in patients with Lennox-Gastaut Syndrome Aaron Warren, PhD University of Melbourne, Australia Highlights: We will study 20 patients who are participating in a recently commenced clinical trial where a…
Modeling Lennox-Gastaut Syndrome in Human Cerebral Organoids Vanesa Nieto-Estevez, PhD UT Southwestern Medical Center Results: Pending CHD2: One Gene, Many Roles Lay Abstract: Lennox–Gastaut syndrome (LGS) is a devastating epileptic encephalopathy in children characterized by multiple seizure types and…
