How is LGS Treated?
It is the LGS Foundation’s mission to fund research into new therapies for LGS. Learn about our research initiatives here. Below is more information about the treatment options available.
Watch: The Latest Treatment Options for LGS
Scott Perry, MD, Medical Director of Neurology & Genetics Epilepsy Center at Cook Children’s Hospital speaks on the latest treatments available for those living with Lennox-Gastaut Syndrome. Dr. Perry also offers insight on how your medical team can determine the best options for your loved one with LGS.
There are numerous treatment types for seizures associated with LGS:
Check out our LGS Learning and Resource Center pages on Treatment Options
Clinical Trials in LGS
Research is ongoing to find novel, innovative treatments for LGS. Clinical trials are research studies performed in those with LGS. They scientifically evaluate a medical or surgical intervention. They are the primary way that researchers find out if a new treatment, like a new drug, diet, or medical device is safe and is effective in reducing seizures in those with LGS.
A 2015 report showed that average yearly medical costs are about $64,000 for LGS. This number depends on insurance status. Hospitalizations and home health services are a big expense. Many medication options are generic and are relatively inexpensive. Newer medications, such as cannabidiol, are more expensive but are generally covered by insurance.
Sometimes, a therapy is denied insurance coverage initially. However, working with a healthcare provider to appeal the decision can help.
LGS always persists into adulthood. Certain types of seizures are more common in adults than others with LGS. Over time, those with LGS experience developmental slowing, plateauing or regression. This culminates in moderate to severe intellectual disability in more than 90% of patients. Behavior disorders are common in childhood and adolescence.
Untreated seizures can lead to head injury and a higher risk of sudden death. LGS requires lifelong antiseizure treatment.
Thank you to the Child Neurology Foundation for allowing us to adapt this article for this site.
Authors: Shaun Ajinkya, MD; Elaine Wirrell, MD, Mayo Clinic – Rochester, Minnesota Reviewed: April 2021
The information here is not intended to provide diagnosis, treatment, or medical advice and should not be considered a substitute for advice from a healthcare professional. Content provided is for informational purposes only. LGSF is not responsible for actions taken based on the information included on this webpage. Please consult with a physician or other healthcare professional regarding any medical or health-related diagnosis or treatment options.
Updated April 10, 2022