GluN2D – dependent maturation of cortical interneurons and epilepsy – co-funded with the American Epilepsy Society Zin-Juan Klaft, PhD Tufts University Results: Coming soon Tonic Activation of GluN2C/GluN2D-Containing NMDA Receptors by Ambient Glutamate Facilitates Cortical Interneuron Maturation Lay Abstract:…
The Effects of Felbamate on the Evolution of LGS Children’s Hospital of Orange County Highlights: Evaluated the efficacy and safety of felbamate for treatment of epileptic spasms Quantified felbamate exposure by calculating peak and weighted-average weight-based dose. Phenotypes with unprovoked…
Dissecting the Interplay Between Genetic and Metabolic Deficits in LGS using Zebrafish Colleen Carpenter, PhD University of California, San Francisco Highlights: Model 40 different single-gene mutations that represents catastrophic childhood epilepsies in zebrafish Evaluate electrophysiological, behavioral, neuro-anatomical, survival and…
RNA Modulation in KCNB1 Model of LGS Jennifer Kearney, PhD Northwestern University Feinberg School of Medicine Highlights: Evaluated mouse model with a Kcnb1-associated LGS mutation. Applied antisense oligo to knockout mutant Kcnb1. Assessed neurological and behavioral symptoms in Kcnb1…
Optimizing Stimulation Parameters for LGS Neuromodulation (OPTISTIM+) Linda Dalic, PhD University of Melbourne, Australia Neurologist/Epileptologist Highlights: Seeks a better understanding of epilepsy neuromodulation in LGS patients. Explores the role of different target and stimulation parameters for LGS patients. Establishes…
Preclinical Optimization of a Non-Invasive Approach to DBS in LGS Highlights: Assesses low-intensity ultrasound for seizure treatment. Targets the centromedian thalamus in mice that have seizures from LGS. Determines the feasibility of applying focused ultrasound as a non-invasive substitute for…
Neurostimulation to Remodel Sleep Architecture in LGS Aaron Warren, PhD Brigham and Women’s Hospital, Harvard Medical School Highlights: Enrolled 20 patients participating in an ongoing clinical trial of dual thalamic and cortical responsive neurostimulation (RNS) Determining the correlation between…
Sleep Evaluation for Children with LGS – A Pilot Study Gita Gupta, MD University of Michigan Highlights: Assesses sleep in children with LGS using a combination of in-clinic and home evaluations, wearable devices, and questionnaires to reveal medical and behavior…
Learn about Lennox-Gastaut Syndrome from those who know it best, the LGS Patient-Family Community. The LGS Foundation is harnessing the power of the patient-family community to ensure that research, care, support services, education, and awareness of LGS are relevant for…
The LGS Foundation was proud to host the DELVE Meeting on Developmental and Epileptic Encephalopathies (DEEs) & Lennox-Gastaut Syndrome (LGS) An Externally-Led Patient-focused drug development (PFDD) meeting on DEEs & LGS On November 1, 2019, the LGS Foundation convened the…
