Clinical Trials in LGS

What is a Clinical Trial?

Clinical trials and research studies are done to scientifically evaluate a medical or surgical intervention. They are the primary way that researchers find out if a new treatment, like a new drug, diet, surgery, or medical device, is safe and effective in reducing seizures in those with LGS.

Without volunteers, these studies cannot exist and we would not be able to find new treatments for LGS and seizures. Families who participate in clinical trials and/or research studies are on the cutting edge of helping us to find better treatments and cures. The reason we have treatments for LGS today is due to the fact that LGS families participated in past trials. We are forever grateful for their contribution.

What are the Phases of a Clinical Trial?

In phase 1 of a clinical trial, researchers test a new drug or treatment in a small group of healthy volunteers and/or people with the disease for the first time and they evaluate its safety, determine a safe dosage range, and identify side effects.
In phase 2, a drug or treatment is given to a larger group of people to see if it is effective for seizures and to further evaluate its safety.
In this phase, the drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely. More than one Phase III study may be required before a New Drug Application (NDA) may be submitted to the FDA.
Once the FDA accepts a filing for the approval of a new treatment, the FDA must complete its review process within 10 months in most cases. The date at the end of the review period is referred to as the Prescription Drug User Fee Act (PDUFA) date.
In this phase, studies are done after the drug or treatment has been FDA-approved and marketed to families. The goal is to gather information on the drug’s effect in various populations and identify any side effects associated with long-term use.

Research is our best hope for advancing treatments and eventually finding a cure for LGS and associated epilepsies. Research is not just the responsibility of scientists and doctors. It is important that patients participate to whatever extent they are able.

Patients can participate in research in several ways, including 1) sharing their information with scientists through patient registries so researchers can understand how LGS affects individuals; and 2) volunteering for clinical studies or trials to help doctors understand how treatments affect patients.

Clinical studies seek to answer questions such as:

  • Does this investigational drug or treatment work?
  • Does it work better than another treatment already available?
  • Does it cause any side effects?
  • Are there any other benefits that could improve patient quality of life?

Since 2011, thanks to community engagement and study participation, 7 new medications have received approval from the FDA for the treatment of LGS.

Should I participate in a Clinical trial?

Learn more here on things to consider before you participate in a trial

What Clinical Trials and Research Studies are Happening in LGS?

The Jazz Piccolo Study

The Jazz Piccolo Study is investigating the safety and effectiveness of cannabidiol (or CBD oral solution) in infants (2 years of age and younger) with Tuberous Sclerosis Complex (TSC), Lennox-Gastaut Syndrome (LGS) or Dravet Syndrome (DS) who experience inadequately controlled seizures.



The LGS DISCOVER study (YKP509C003) is looking to see whether an investigational medicine called carisbamate can decrease the number of seizures in children and adults aged 4-55 years with LGS when given alongside antiseizure medications (ASMs).


RNS System Clinical Trial

This study examines the safety and effectiveness of Responsive Neurostimulation (RNS) for reducing seizures in individuals 12 years of age or older with LGS.


STARS Phase 3 Staccato Alprazolam Study

The STARS Phase 3 Staccato Alprazolam Study is designed for people who experience prolonged epileptic seizures lasting more than 3 minutes. It tests an inhaler containing an investigational drug to see whether it could help people who experience prolonged epileptic seizures.


SOM-L Research Study: Surgery or Medication for LGS, Comparing Two Treatments

In this study, the research team is comparing outcomes among children with LGS who receive medicine or surgery. The team is comparing healthcare use, behavior, and physical function between children.


No Longer Recruiting – Pending Results:

This anti-seizure medicine slows down the activation of the enzyme cholesterol 24-hydroxylase (CH24H). It has the potential to reduce seizure susceptibility and improve seizure control. It is currently in phase 3 studies for those with LGS. 

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The PACIFIC Study is a Phase 1b/2a clinical study for adult participants with DEEs. This study will assess the safety & tolerability of LP352. Importantly, the PACIFIC study is also designed to examine changes in seizure frequency over the treatment period.

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The Stellina Study is a Phase 1/2a clinical study evaluating a single dose of diazepam nasal spray (VALTOCO) as a rescue medication in children aged 2-5 who have been diagnosed with epilepsy. The objectives of the study are to assess the pharmacokinetics (PK) of diazepam after one intranasal dose of VALTOCO as well as assess the long-term safety and tolerability in the six-month open-label safety period.

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Learn More about Clinical Trials

  For more information about clinical trials, visit NIH,

Interested in sharing clinical trial information? View our Clinical Trial Partners Guidelines here.

Updated 02/26/2024