2019 Grant Recipient – Zin-Juan Klaft
GluN2D – dependent maturation of cortical interneurons and epilepsy – co-funded with the American Epilepsy Society
Dr. Zin-Juan Klaft, PhD
Impaired cortical inhibition occurs in many difficult-to-treat epilepsies and can originate from developmental disruptions of inhibitory circuit maturation. Recently, human GluN2D mutations were shown to cause severe epileptic encephalopathies. Based on previous data and clinical studies, disturbing early-life GluN2D signaling may lead to dysfunctional cortical inhibition and epilepsy. With further testing, we seek to determine how these signal disturbances contribute to epilepsy.
The LGS Foundation accepts unsolicited proposals year-round to seed new basic, translational, and clinical research projects on LGS. Projects may be funded at the $25,000, $50,000, or $75,000 level.