LGS Foundation Research Grant Program

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Our 2021 Research Grant Cycle: OPENS 2/1/21

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The LGS Foundation's seed grant program awards one-year research grants up to $30,000 and two-year grants up to $50,000 (the LGS Foundation does not permit indirect costs) to young investigators, physician residents, and clinicians who are interested in studying Lennox-Gastaut Syndrome. Our seed grants are intended to help researchers explore novel ideas and answer questions related to the clinical aspects, therapies, causes, and evolution of LGS.

Grant recipients are asked to give a presentation at the LGS Foundation's research meeting at the American Epilepsy Society the following year to discuss their work.

 

Areas of Interest:

• Causes of LGS and increasing our understanding of the underlying biology

• Evolution of LGS from intractable seizures to Slow Spike & Wave on EEG

• Evolution of tonic seizure (GPFA on EEG) in LGS

• Evolution of multiple seizure types in young children, which may lead to future LGS

• Understanding convulsive/non-convulsive status epilepticus and cluster seizures in LGS

• Therapies to prevent or treat Lennox-Gastaut Syndrome

• Quality of Life for individuals living with LGS and their families

• Epidemiology and better data collection/management of data from individuals of LGS

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2021 FUNDING PROGRAM

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Program Opens - February 1, 2021

Full Applications Due - June 1, 2021

Award Announcement - August 16, 2021

Anticipated Project Start Date - October 1, 2021

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Click here for full RFA 

2019 Recipients

Colleen Carpenter, PhD

University of California, San Francisco

"Dissecting the interplay between genetic and metabolic deficits in LGS using Zebrafish"

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Daniel Shrey, MD,  Beth Lopour, MD & Mary Zupanc, MD

Children's Hospital of Orange County 

UC Irvine

"The effects of Felbamate on the evolution of LGS"

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Zin-Juan Klaft, PhD

Tufts University

"GluN2D - dependent maturation of cortical interneurons and epilepsy"

*co-funded with the American Epilepsy Society

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2018 Recipient

Kay-Marie Lamar, PhD

Northwestern University

"Defining the Molecular Mechanisms of CHD2 in LGS"

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2017 Recipients

Vanesa Nieto-Estevez, PhD

UT Southwestern Medical Center

"Modeling Lennox-Gastaut Syndrome in Human Cerebral Organoids"

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Aaron Warren, PhD Candidate

Melbourne Brain Centre

"Identifying neuroimaging predictors of treatment outcomes following deep brain stimulation in patients with Lennox-Gastaut syndrome"

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2016 Recipients

Nicholas Poolos, MD, PhD

University of Washington

Department of Neurology

"Large scale analysis of antiepileptic drug efficacy in Lennox-Gastaut Syndrome" 

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2015 Recipients

Robert Hunt, PhD

University of California Irvine

Department of Anatomy & Neurobiology

Robert Hunt Lab 

"CHD2 model for LGS" 

Candace Myers, PhD

University of Washington 

Department of Pediatrics, Division of Genetic Medicine

"Identifying Genetic Causes of LGS" 

2014 Recipients

Brian Grone, PhD

Epilepsy Research Laboratory

Department of Neurological Surgery

University of California, San Francisco

*A Zebrafish Model for LGS*

Thiele, Elizabeth, MD, PhD

Director, Pediatric Epilepsy Program

Massachusetts General Hospital 

"Low Glycemic Index Treatment in Patients with LGS"

2021 Cycle Opens February 1, 2021.  Application Deadline June 1, 2021.   Awards Announced August 16, 2021

APPLICATION GUIDELINES

Application Instructions:

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• Applications must be submitted by the deadline to and must include the following.

• Title Page: Enter proposal title and PI information.

• Abstract: Provide a lay summary and a scientific summary of the project.

• Budget Period Detail: Provide a detailed budget and justification. All expenses must in U.S. dollars.

• Proposal (NIH format is acceptable)

• Biosketch for each PI

• Letters of support or collaboration as relevant

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Application Deadline is June 1, 2021.

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Click here for full RFA 

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International Applicants Welcome. Please submit complete packet of documents to:

tracy@lgsfoundation.org