LGS Foundation Research Grant Program
Our 2020 Research Grant Cycle is now Closed.
The LGS Foundation's seed grant program awards one-year research grants up to $30,000 and two-year grants up to $50,0000 (the LGS Foundation does not permit indirect costs) to young investigators, physician residents, and clinicians who are interested in studying Lennox-Gastaut Syndrome. Our seed grants are intended to help researchers explore novel ideas and answer questions related to the clinical aspects, therapies and/or genetic causes of LGS.
Grant recipients are asked to give a presentation at the LGS Foundation's research meeting at the American Epilepsy Society the following year to discuss their work.
The LGS Foundation does not require an LOI. However, we will evaluate LOI's from investigators prior to submission of a full application.
Areas of Interest:
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Causes of LGS and increasing our understanding of the underlying biology
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Evolution of LGS from intractable seizures to Slow Spike & Wave on EEG
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Evolution of tonic seizure (GPFA on EEG) in LGS
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Evolution of multiple seizure types in young children, which may lead to future LGS
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Understanding convulsive/non-convulsive status epilepticus and cluster seizures in LGS
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Therapies to prevent or treat Lennox-Gastaut Syndrome
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Quality of Life for individuals living with LGS and their families
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Epidemiology and better data collection/management of data from individuals of LGS
2020 FUNDING PROGRAM
Program Opens - February 1, 2020
Full Applications Due - June 1, 2020
Award Announcement - August 15, 2020
Anticipated Project Start Date - September 15, 2020
2019 Recipients
Colleen Carpenter, PhD
University of California, San Francisco
"Dissecting the interplay between genetic and metabolic deficits in LGS using Zebrafish"
Daniel Shrey, MD, Beth Lopour, MD & Mary Zupanc, MD
Children's Hospital of Orange County
UC Irvine
"The effects of Felbamate on the evolution of LGS"
Zin-Juan Klaft, PhD
Tufts University
"GluN2D - dependent maturation of cortical interneurons and epilepsy"
*co-funded with the American Epilepsy Society
2018 Recipient
Kay-Marie Lamar, PhD
Northwestern University
"Defining the Molecular Mechanisms of CHD2 in LGS"
2017 Recipients
Vanesa Nieto-Estevez, PhD
UT Southwestern Medical Center
"Modeling Lennox-Gastaut Syndrome in Human Cerebral Organoids"
Aaron Warren, PhD Candidate
Melbourne Brain Centre
"Identifying neuroimaging predictors of treatment outcomes following deep brain stimulation in patients with Lennox-Gastaut syndrome"
2016 Recipients
Nicholas Poolos, MD, PhD
University of Washington
Department of Neurology
"Large scale analysis of antiepileptic drug efficacy in Lennox-Gastaut Syndrome"
2015 Recipients
Robert Hunt, PhD
University of California Irvine
Department of Anatomy & Neurobiology
Robert Hunt Lab
"CHD2 model for LGS"
Candace Myers, PhD
University of Washington
Department of Pediatrics, Division of Genetic Medicine
"Identifying Genetic Causes of LGS"
2014 Recipients
Grone, Brian, PhD
Epilepsy Research Laboratory
Department of Neurological Surgery
University of California, San Francisco
*A Zebrafish Model for LGS*
Thiele, Elizabeth, MD, PhD
Director, Pediatric Epilepsy Program
Massachusetts General Hospital
"Low Glycemic Index Treatment in Patients with LGS"
Seed Grants
Available to young and established investigators. No indiret costs are awarded. LOI's are not required but the LGSF will review an LOI prior to submission of full proposal.
Up to $30,000 - One Year Grant
Post-Doctoral Fellowships
PhDs or MDs are encouraged to apply. The grant recipient must spend at least 40% of their professional time engaged in activities related to Lennox-Gastaut Syndrome throughout the duration of their award. Applications must show relevance to one of the LGSF's targeted research areas.
$25,000/year - Two Year Grant
2020 Cycle Opens February 1, 2020. Application Deadline June 1, 2020. Awards Announced July 15, 2020
APPLICATION GUIDELINES
LOI Information
NOTE: LOIs are welcome but not required.
LOI must clearly outline hypothesis and aims and include description of how research will benefit patients with LGS. Maximum 2 pages.
LOI deadline: April 1, 2020
Application Instructions:
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Applications must be submitted by the deadline to and must include the following.
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Title Page: Enter proposal title and PI information.
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Abstract: Provide a lay summary and a scientific summary of the project.
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Budget Period Detail: Provide a detailed budget and justification. All expenses must in U.S. dollars.
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Proposal (NIH format is acceptable)
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Biosketch for each PI
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Letters of support or collaboration as relevant
Application Deadline is June 1, 2020.
International Applicants Welcome. Please submit complete packet of documents to:
