LGS Research Grant Program

​Our 2021 Research Grant Cycle: CLOSED​

The LGS Foundation’s seed grant program awards one-year research grants up to $30,000 and two-year grants up to$50,000 (the LGS Foundation does not permit indirect costs) to young investigators, physician residents, and clinicians who are interested in studying Lennox-Gastaut Syndrome. Our seed grants are intended to help researchers explore novel ideas and answer questions related to the clinical aspects, therapies, causes, and evolution of LGS.

Grant recipients are asked to give a presentation at the LGS Foundation’s research meeting at the American Epilepsy Society the following year to discuss their work.

Areas of Interest:

  • Causes of LGS and increasing our understanding of the underlying biology
  • Evolution of LGS from intractable seizures to Slow Spike & Wave on EEG
  • Evolution of tonic seizure (GPFA on EEG) in LGS
  • Evolution of multiple seizure types in young children, which may lead to future LGS
  • Understanding convulsive/non-convulsive status epilepticus and cluster seizures in LGS
  • Therapies to prevent or treat Lennox-Gastaut Syndrome
  • Quality of Life for individuals living with LGS and their families
  • Epidemiology and better data collection/management of data from individuals of LGS

2021 Funding Program

  • Program Opens – February 1, 2021
  • Full Applications Due – June 1, 2021
  • Award Announcement – August 16, 2021
  • Anticipated Project Start Date – October 1, 2021


Seed Grants
Up to $30,000 – One Year Grant

Available to young and established investigators. No indirect costs are awarded. LOI’s are not required but the LGSF will review an LOI prior to submission of the full proposal.

Post-Doctoral Fellowships
$25,000/year – Two Year Grant

PhDs or MDs are encouraged to apply. The grant recipient must spend at least 40% of their professional time engaged in activities related to Lennox-Gastaut Syndrome throughout the duration of their award. Applications must show relevance to one of the LGSF’s targeted research areas.


2021 Recipient

  • Jennifer A. Kearney, Ph.D.
    Northwestern University Feinberg School of Medicine
    RNA Modulation in KCNB1 Model of LGS

2019 Recipients

  • Colleen Carpenter, Ph.D.
    University of California, San Francisco
    Dissecting the interplay between genetic and metabolic deficits in LGS using Zebrafish
  • Daniel Shrey, M.D.,  Beth Lopour, M.D. and Mary Zupanc, M.D.
    Children’s Hospital of Orange County
    The effects of Felbamate on the evolution of LGS
  • Zin-Juan Klaft, Ph.D.
    Tufts University
    GluN2D – dependent maturation of cortical interneurons and epilepsy – co-funded with the American Epilepsy Society

2018 Recipient

  • Kay-Marie Lamar, Ph.D.
    Northwestern University
    Defining the Molecular Mechanisms of CHD2 in LGS

2017 Recipients

  • Vanesa Nieto-Estevez, Ph.D.
    UT Southwestern Medical Center
    Modeling Lennox-Gastaut Syndrome in Human Cerebral Organoids
  • Aaron Warren, Ph.D.
    Melbourne Brain Centre
    Identifying neuroimaging predictors of treatment outcomes following deep brain stimulation in patients with Lennox-Gastaut syndrome

2016 Recipient

  • Nicholas Poolos, M.D., Ph.D.
    University of Washington
    Large scale analysis of antiepileptic drug efficacy in Lennox-Gastaut Syndrome

2015 Recipients

  • Robert Hunt, Ph.D.
    University of California Irvine
    CHD2 model for LGS
  • Candace Myers, Ph.D.
    University of Washington
    Identifying Genetic Causes of LGS

2014 Recipients

  • Brian Grone, Ph.D.
    University of California, San Francisco
    A Zebrafish Model for LGS
  • Thiele, Elizabeth, M.D., Ph.D.
    Massachusetts General Hospital
    Low Glycemic Index Treatment in Patients with LGS

2021 Cycle Opens February 1, 2021.  

Application Deadline June 1, 2021.  

Awards Announced August 16, 2021

Application Guidelines

Application Instructions:
  • Applications must be submitted by the deadline to Tracy@LGSfoundation.org and must include the following.
  • Title Page: Enter proposal title and PI information.
  • Abstract: Provide a lay summary and a scientific summary of the project.
  • Budget Period Detail: Provide a detailed budget and justification. All expenses must in U.S. dollars.
  • Proposal (NIH format is acceptable)
  • Biosketch for each PI
  • Letters of support or collaboration as relevant

The application deadline is June 1, 2021.

Click here for full RFA 

International Applicants Welcome.